It provides uvb absorption as well as some absorption in uva region 320340 nm. Hydroxy4methoxybenzophenone, also known as benzophenone 3 bp 3, is a commonly used ultraviolet filter in skincare and as a food additive. They are both very stable and protect and augment other uv absorbers. Apoptosis induced by the uv filter benzophenone3 in mouse. Urinary measurements of bp3 have been used as a biomarker of exposure. Benzophenone3 is proposed to be continued for use in sunscreen products at a maximum concentration at 10% weightweight. Recall that oxidation is a loss of electrons while reduction is a gain of electrons oil rig. Oxybenzone or benzophenone 3 or bp 3 trade names milestab 9, eusolex 4360, escalol 567, kahscreen bz 3 is an organic compound. Benzophenone3 bp3 benzophenone3 bp3 is a naturally occurring chemical found in some flowering plants. Sunscreen octocrylene, ethylhexyl methoxycinnamate, benzophenone3, butyl methoxydibenzoylmethane stick out of scope out of scope for rxnorm and will not receive rxnorm normal forms. Oxybenzone, also known as benzophenone3, is an organic.
Toxicopathological effects of the sunscreen uv filter. Benzophenone4 is readily soluble in water, propylene glycol, glyerin, ethanol and isopropyl alcohol. Date hs code description origin country port of discharge unit quantity value inr per unit inr nov 09 2016. Bp 3 absorbs and scatters the suns harmful ultraviolet uv rays. Cosmetics containing ingredients linked to cancer or. Diane dietz january 25, 2018 page 2 your company sells a number of products containing benzophenone, and is required under californias safe drinking water and toxic enforcement act of 1986, commonly known. Benzophenone 3 oxybenzone and benzophenone 4 sulisobenzone are chemical uv absorbers solid powder at normal temperature.
Concentrations of the sunscreen agent benzophenone3 in residents of the united states. It is a naturally occurring chemical found in various flowering plants as well as being an organic component of many. Pdf hydroxy4methoxybenzophenone, also known as benzophenone3 bp3, is a commonly used ultraviolet filter in skincare and as a food additive find. Benzophenone3 oxybenzone is used in many sunscreens and some other personal care products to protect skin from sun damage. Jan 28, 2020 sunscreen octocrylene, ethylhexyl methoxycinnamate, benzophenone3, butyl methoxydibenzoylmethane stick out of scope out of scope for rxnorm and will not receive rxnorm normal forms. Oxybenzone or benzophenone3 or bp3 trade names milestab 9, eusolex 4360, escalol 567, kahscreen bz3 is an organic compound. Where the world comes to its senses berje is a global distributor of essential oils and aromatic chemicals. Safety data sheet according to 29cfr19101200 and ghs rev.
Benzophenone3, or oxybenzone, primarily functions as a photostabilizer and sunscreen. The list of cosmetic products below is a selection of the most requested cosmetics that contain the ingredient benzophenone3. Benzophenone 4 is readily soluble in water, propylene glycol, glyerin, ethanol and isopropyl alcohol. Hazardous in case of skin contact irritant, sensitizer, of eye contact irritant, of ingestion, of inhalation. Inadequate when used alone, benzophenone3 absorbs uvb and short uva rays but is a relatively weak chemical uv absorber.
Nevertheless, metabolic transformation pathway and the transformation products of bp3 in. The inci name for this ingredient is benzophenone3. Among the vast selection of sunscreen active ingredients, benzophenone3 is classified as a chemical sunscreen agent. It was clear to see that after 3 to 5 days after the last application there was. Oxybenzone is an emerging contaminant of concern in marine environmentsproduced by swimmers and municipal, residential, and boatship wastewater discharges. Introduction background we use the term cosmetics in this report to denote a wide variety of personal care products used by people of all genders and ages. Benzophenone3 2hydroxy4methoxybenzophenone, oxybenzone, 2oh4 meobp or bp3 is a commonly used sunscreen agent, absorbing. Applications galsorb benzophenone3 being a broadband uv filter, it can be used in day cream to prevent aging of skin and to protect the lips.
Widespread exposure of humans to benzophenone3 bp3 is a concern due to this compounds potential to disrupt endocrine function. Benzophenone3 bp3 is a naturally occurring chemical found in some flowering plants. Doubly bonded ep and be15 molecules and their reactions with h2, acetonitrile, benzophenone, and 2,3dimethylbutadiene. Benzophenone 3, listed as oxybenzone, and benzophenone 4 and 5, listed as sulisobenzone and sulisobenzone sodium, respectively, are included in annex vii, part 1 uv filter which cosmetic products may contain of the cosmetics directive of the european union. Derivatives of benzophenone, such as benzophenone 2 bp2 and oxybenzone benzophenone 3 or bp3 are common ingredients in sunscreen. Determination of trace levels of benzophenonetype ultraviolet filters in real matrices by bar adsorptive microextraction using selective sorbent phases. Bp3 can be metabolized by phase i and phase ii reactions of the human cytochrome p450 system. National health and nutrition examination survey 20032004. Oxybenzone belongs to the class of aromatic ketones known as benzophenones. A comparative study for all adsorbents with batch adsorption experiments was achieved to determine the optimal conditions. The list of cosmetic products below is a selection of the most requested cosmetics that contain the ingredient benzophenone 3. Benzophenone 3 is also added to packaging and some consumer products, such as cosmetics and paints, to protect the products from sun damage. Hydroxy4methoxybenzophenone, also known as benzophenone3 bp3, is a commonly used ultraviolet filter in skincare and as a food additive. Bp 3 is also added to packaging and some consumer products, such as cosmetics and paints, to protect the products from sun damage.
Because it is not yet known how long the material is stored, or whether it is important, gonzalez suggested that parents of small children avoid using sunscreens that contain benzophenone 3, to be on the safe side. Exposure to benzophenone3 and reproductive toxicity. Large concentrations of similar phenolic compounds have been detected in urine, amniotic fluid, and placental tissue, thereby. This study aimed to 1 provide descriptive information about prostate specific antigen levels and 2 examine the association. The capability of benzophenone3 bp3 to absorb and dissipate. Exposure may occur by using consumer products that contain benzophenone. Bp3 absorbs and scatters the suns harmful ultraviolet uv rays. In an investigation carried out 25 people applied sun cream, containing 4% oxybenzone, twice a day over 5 consecutive days. Combustion products may include carbon oxides or other toxic vapors. Concentrations of the sunscreen agent benzophenone3 in.
Bp3 also has been used as ultraviolet stabilizer in plastic surface coatings for food packaging to prevent polymer or. Benzophenone3 oxybenzone, benzophenone4 sulisobenzone. Oxybenzone is an emerging contaminant of concern in marine environmentsproduced by swimmers and. The benzophenone is activated by uv light to an extremely reactive tripletstate ketone, which can insert into ch, nh, and other structures, resulting in a covalent bond chapter 3, section 7. Benzophenone is the organic compound with the formula c 6 h 5 2 co, generally abbreviated ph 2 co. Dermal uptake of benzophenone3 from clothing environmental. Benzophenone3 oxybenzone and benzophenone4 sulisobenzone are chemical uv absorbers solid powder at normal temperature.
Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and food. It is a paleyellow solid that is readily soluble in most organic solvents. For this reason, it is produced for use as sunscreen in lotions, conditioners, and cosmetics. Benzophenone3 bp3 factsheet national biomonitoring. Archives of environmental contamination and toxicology, 702, 265288. Benzophenone3 2hydroxy4methoxybenzophenone, oxybenzophenone bp3, a commonly used sunscreen agent that absorbs and dissipates ultraviolet radiation, is used in a variety of cosmetic products gonzalez et al. Fourth national report on human exposure to environmental. According to the study, the average total amount of benzophenone3 excreted was 3. Background submission i on the uvfilter oxybenzone the inn name, also known as benzophenone3 or 2hydroxy4methoxybenzone, has been submitted by colipa1. Applications galsorb benzophenone 3 being a broadband uv filter, it can be used in day cream to prevent aging of skin and to protect the lips. Moreover it seems that oxybenzone can build up in the body.
Benzophenone 3 is proposed to be continued for use in sunscreen products at a maximum concentration at 10% weightweight. Hazards identification potential acute health effects. Galsorb benzophenone 3 is an oil soluble sunscreen agent. Parameter result benzophenone3 octocrylene octinoxate octisalate retention time min 6. Both cover uvb and short uva uva2 range but are relatively weak sunscreens, inadequate when used alone.
The suspected endocrine disruptor bp3 has been detected in the air and settled dust of homes and is expected to redistribute from its original sources to other indoor compartments, including clothing. These chemicals are not listed under proposition 65. Oct 10, 2008 according to the study, the average total amount of benzophenone 3 excreted was 3. Benzophenone 119619 100 toxicological data on ingredients. Toxicopathological effects of the sunscreen uv filter, oxybenzone. Benzophenone3 also known as bp3 or oxybenzone is added to sunscreens, plastics, and some coatings to filter uv radiation. The capability of benzophenone 3 bp 3 to absorb and dissipate ultraviolet radiation facilitates its use as a sunscreen agent. Dermal uptake of benzophenone3 from clothing dtu orbit. Benzophenone is a different chemical than benzophenone3 also called oxybenzone and benzophenone4 also called sulisobenzone.
Benzophenone 3 also known as bp 3 or oxybenzone is added to sunscreens, plastics, and some coatings to filter uv radiation. Pdf concentrations of the sunscreen agent benzophenone3. Colipa letter stating that the use level of bp3 as a uvfilter does not exceed 6% for. Apr 07, 2017 benzophenone3 bp3 is a naturally occurring chemical found in some flowering plants. Biotinpeg 3 benzophenone is a biotinylation reagent with a hydrophilic spacer containing three ethylene oxide units and a photoreactive group at its end quanta biodesign figure 18. Benzophenone3 is also added to packaging and some consumer products, such as cosmetics and paints, to protect the products from sun damage. The companys origins and strength lie in a profound understanding of the supply and the. Benzophenone is a widely used building block in organic chemistry, being the parent diarylketone. Reliance value innovation shanghai sunwise chemical co. Cosmetics containing ingredients linked to cancer or reproductive harm 3 california department of public health california safe cosmetics program august 2016 part 1. Oxybenzone may be used at concentrations up to 10%, and products containing 0.
Often benzophenone is used in combination with other chemical absorbing sunscreens to augment and stabilise the final product. Many of these chemicals have been shown to have adverse effects on reproductive organs and hormones, both in vitro and in vivo. The current submission contains the following documents. Benzophenone 3, or oxybenzone, primarily functions as a photostabilizer and sunscreen. The benzophenone is activated by uv light to an extremely reactive tripletstate ketone, which can insert into ch, nh, and other structures, resulting. Benzophenone3, listed as oxybenzone, and benzophenone4 and 5, listed as sulisobenzone and sulisobenzone sodium, respectively, are included in annex vii, part 1 uv filter which cosmetic products may contain of the cosmetics directive of the european union. Bp3 is also added to packaging and some consumer products, such as cosmetics and paints, to protect the products from sun damage.
Effects of oxybenzone benzophenone3 on phytoplakton. It is a white solid that is soluble in organic solvents. The suspected endocrine disruptor bp 3 has been detected in the air and settled dust of homes and is expected to redistribute from its original sources to other indoor compartments, including clothing. In this study, the adsorption of a hydrophobic molecule, benzophenone3 bz3 was investigated onto three adsorbents. Large concentrations of similar phenolic compounds have been detected in urine, amniotic fluid, and placental tissue, thereby raising questions about its impact on reproduction. Please login to display the rating of all cosmetics. It is a naturally occurring chemical found in various flowering.
Galsorb benzophenone3 is an oil soluble sunscreen agent. Derivatives of benzophenone, such as benzophenone2 bp2 and oxybenzone benzophenone3 or bp3 are common ingredients in sunscreen. Given its physical and chemical properties, we hypothesized that. Benzophenone is used in personal care products such as lip balm and nail polish to protect the products from uv light.
Benzophenone is persistent, bioaccumulative and toxic pbt. Three groups each of four female mice were treated daily with benzophenone3 at concentrations of 12. Benzophenone 3 bp 3 is a naturally occurring chemical found in some flowering plants. Berje is a familyowned business that has been in operation for six decades. Health sciences research commons gw research days 2016. It is a broad spectrum sunscreen active with maximal uv absorbance in the 320400 nm range uva.
Sds of benzophenone, safety data sheets, cas 119619. The effects of the main experimental parameters were determined such. Benzophenone is a different chemical than benzophenone 3 also called oxybenzone and benzophenone 4 also called sulisobenzone. Pdf exposure to benzophenone3 and reproductive toxicity. Because it is not yet known how long the material is stored, or whether it is important, gonzalez suggested that parents of small children avoid using sunscreens. Biphenyl occurs as colorless leaflets that are insoluble in water. Among the vast selection of sunscreen active ingredients, benzophenone 3 is classified as a chemical sunscreen agent. The capability of benzophenone3 bp3 to absorb and dissipate ultraviolet radiation facilitates its use as a sunscreen agent. Background submission i on the uvfilter oxybenzone the inn name, also known as benzophenone 3 or 2hydroxy4methoxybenzone, has been submitted by colipa1. Feb 01, 2019 in this study, the adsorption of a hydrophobic molecule, benzophenone 3 bz 3 was investigated onto three adsorbents. Inadequate when used alone, benzophenone 3 absorbs uvb and short uva rays but is a relatively weak chemical uv absorber.